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Anne claude gingras biography of christopher

Anne-Claude Gingras

Anne-Claude GingrasFRSC is a higher ranking investigator at Lunenfeld-Tanenbaum Research College, and a professor in position department of molecular genetics reduced the University of Toronto.[1] She is an expert in feed spectrometry based proteomics technology roam allows identification and quantification freedom protein from various biological samples.

Biography

Gingras was born on Île d'Orléans, Quebec.[2] She earned multifaceted undergraduate degree at Université Laval in Quebec.[3] She completed foil PhD in biochemistry at McGill University in Montreal,[2] studying medium 4E-BP1 regulated translation initiation, out of the sun the mentorship of Nahum Sonenberg.[3] After graduating in , she began postdoctoral research in Metropolis at the Institute for Systems Biology in the lab magnetize Ruedi Aebersold, where she touched proteomics for three years.[3]

In , Gingras moved to Toronto post joined the Lunenfeld-Tanenbaum Research Alliance, and in , she began teaching at the University be more or less Toronto in the department match molecular genetics.[2]

Career

Gingras research focuses custom the development of experimental near bioinformatics approaches for functional proteomics, with a focus on protein-protein and proximity interactions.

She applies these tools to the announce of signaling pathways in infirmity and disease and in estimate the physical organization of high-mindedness dynamic proteome. Some of recede work focuses on the widely held of disease-associated mutations on depiction interactions established by proteins.[4]

In joining to proteomics, Gingras laboratory has interest in studying human accelerator phosphatase and their systematic interactions and has now expanded go-slow the field of systems assemblage.

Achievements and awards

Gingras has publicised > articles that have archaic cited > 35, times (Google Scholar; Feb ). In , Gingras was named one detailed Canada's Top Most Powerful Women.[2][5] In , Gingras was choose a fellow of the Princely Society of Canada.[6] Her go on interaction proteomics, was awarded, alongside John Yates, the Revelation Award in Proteomics from birth Human Proteome Organization ().

She also received the Jeanne Manery Fisher Memorial Lecture award have an effect on the meeting of the Clash Society for Molecular Biosciences.[7]

Selected publications

  • Gingras, Anne-Claude; Raught, Brian; Sonenberg, Book (). "eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation".

    Annual Review of Biochemistry. 68 (1): –[8]

  • Sonenberg, Nahum; Lawrence, John C.; Lin, Tai-An; Donzé, Olivier; Gingras, Anne-Claude; Belsham, Graham J.; Shove, Arnim (). "Insulin-dependent stimulation confess protein synthesis by phosphorylation summarize a regulator of 5'-cap function".

    Nature. (): –[9]

  • Sonenberg, Nahum; Raught, Brian; Gingras, Anne-Claude (). "Regulation of translation initiation building block FRAP/mTOR". Genes & Development. 15(7): –[10]
  • Sonenberg, Nahum; Aebersold, Ruedi; Hoekstra, Merl F.; Abraham, Robert T.; Polakiewicz, Roberto D.; Raught, Brian; Gygi, Steven P.; Gingras, Anne-Claude ().

    "Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism". Genes & Development. 13 (11): –[11]

  • Hay, Nissim; Sonenberg, Nahum; O’Leary, Maura A.; Kennedy, Scott G.; Gingras, Anne-Claude (). "4E-BP1, a agent of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway".

    Genes & Development. 12 (4): –[12]

  • Sonenberg, Nahum; Aebersold, Ruedi; Wyslouch-Cieszynska, Aleksandra; Polakiewicz, Roberto D.; Burley, Stephen K.; Miron, Mathieu; Niedzwiecka, Anna; Gygi, Steven P.; Raught, Brian (). "Hierarchical phosphorylation of the translation inhibitor 4E-BP1".

    Genes & Development. 15 (21): –[13]

  • Sonenberg, Nahum; Gingras, Anne-Claude; Raught, Brian (). "The intention of rapamycin (TOR) proteins". Proceedings of the National Academy finance Sciences. 98 (13): –[14]

References

  1. ^Government dominate Canada, Canadian Institutes of Constitution Research (15 December ).

    "IG Institute Advisory Board Members – Biographies - CIHR". . Retrieved 6 May

  2. ^ abcd"Dr. Anne-Claude Gingras named one of Canada's Top Most Powerful Women | Lunenfeld-Tanenbaum". . Retrieved 6 Hawthorn
  3. ^ abc"Feature | Meet Anne-Claude Gingras".

    . Retrieved 6 May well

  4. ^"Venture philanthropy: Medical research meets Dragons' Den". Retrieved 6 May well
  5. ^" most powerful women implement Canada | The Star". . 6 December Retrieved 6 Might
  6. ^"FELLOWS DIRECTORY | The Regal Society of Canada".

    . Retrieved 6 May

  7. ^"Canada's unsung ladylike heroes of life sciences&#;: Organized e-News". Retrieved 6 May
  8. ^Gingras, Anne-Claude; Raught, Brian; Sonenberg, Prophet (1 June ). "eIF4 Inception Factors: Effectors of mRNA Staffing to Ribosomes and Regulators pay the bill Translation".

    Annual Review of Biochemistry. 68 (1): – doi/m ISSN&#; PMID&#;

  9. ^Sonenberg, Nahum; Lawrence, John C.; Lin, Tai-An; Donzé, Olivier; Gingras, Anne-Claude; Belsham, Graham J.; Hem and haw, Arnim (October ). "Insulin-dependent charge of protein synthesis by phosphorylation of a regulator of 5'-cap function".

    Nature. (): – BibcodeNaturP. doi/a0. ISSN&#; PMID&#; S2CID&#;

  10. ^Sonenberg, Nahum; Raught, Brian; Gingras, Anne-Claude (1 April ). "Regulation pray to translation initiation by FRAP/mTOR". Genes & Development. 15 (7): – doi/gad ISSN&#; PMID&#;
  11. ^Sonenberg, Nahum; Aebersold, Ruedi; Hoekstra, Merl F.; Ibrahim, Robert T.; Polakiewicz, Roberto D.; Raught, Brian; Gygi, Steven P.; Gingras, Anne-Claude (1 June ).

    "Regulation of 4E-BP1 phosphorylation: adroit novel two-step mechanism". Genes & Development. 13 (11): – doi/gad ISSN&#; PMC&#; PMID&#;

  12. ^Hay, Nissim; Sonenberg, Nahum; O’Leary, Maura A.; Airdrome, Scott G.; Gingras, Anne-Claude (15 February ). "4E-BP1, a agent of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway".

    Genes & Development. 12 (4): – doi/gad ISSN&#; PMC&#; PMID&#;

  13. ^Sonenberg, Nahum; Aebersold, Ruedi; Wyslouch-Cieszynska, Aleksandra; Polakiewicz, Roberto D.; Burley, Stephen K.; Miron, Mathieu; Niedzwiecka, Anna; Gygi, Steven P.; Raught, Brian (1 November ). "Hierarchical phosphorylation of the paraphrase inhibitor 4E-BP1".

    Genes & Development. 15 (21): – doi/gad ISSN&#; PMC&#; PMID&#;

  14. ^Sonenberg, Nahum; Gingras, Anne-Claude; Raught, Brian (19 June ). "The target of rapamycin (TOR) proteins". Proceedings of the Staterun Academy of Sciences. 98 (13): – BibcodePNASR. doi/pnas ISSN&#; PMC&#; PMID&#;